Marijuana – An Exploration (Part 4 – CBD)

CBD

It’s time to move on to another (in a way, THE other) cannabinoid of importance in relation to this discussion. That cannabinoid is CBD. A cannabinoid that is increasingly characterized by its absence in a great many strains of unregulated marijuana crops being sold these days. Granted, strains lacking the cannabinoid to various degrees are available legally. The difference being that in this avenue, you KNOW and can make a choice. As opposed to being tied to whatever your dealers can scrap out of their supply chain. Which tends to be the good stuff.

It’s just the law of the market. There is far more money in high potency strains for repeat users than there is in more mellow CBD heavy stains for novice to infrequent users. Or to put it another way, yet another area in which the decades-long status quo has created a huge problem for society.

One good example of this is the extreme scaremongering argument that is “Marijuana = Schizophrenia!”. It is true that there can be an association. However, did you know that CBD has a role to play here as well? In particular, that it’s absence is a big reason why high potency THC strains can serve as a trigger to problems far from just the mere munchies?

https://www.youtube.com/watch?v=_DlFcMWdsxw

https://www.leafly.ca/news/cannabis-101/whats-the-deal-with-these-high-cbd-strains

I love Marketplace. The show is worth ten times its cost in educational value. It was this episode that initially turned me onto the important role in which CBD plays, to begin with.

Though legalized marijuana and THC products are relative newcomers to the market (well, the above ground market), CBD has been available even previous to legalization in some areas. Since it’s not inherently psychoactive, many jurisdictions didn’t object it being derived or sale. Granted, the finished product had to stay a threshold of 0.5 to 4% THC content (depending on the locality) in order to remain legal.

Unsurprisingly, this substance (particularly CBD oil) is starting to make a splash in the alternative health scene. Though the cannabinoid mirrors THC in the lack of detailed information that we have on the substance, this has yet to stop snake oil salesman from making bold claims about its medicinal properties. Some that go all the way to citing it as a cure to autism.

Part of this is the hands-off nature in which supplements are regulated in the United States, and elsewhere. It’s easy to get your foot in the door when there is no one standing guard. FDA and Health Canada’s regulation for supplements is a joke.

As proven by marketplace!

https://www.youtube.com/watch?v=pCADoLKMSFc

So, much like marijuana, the same obvious rules apply here. Don’t let the overzealous and unethical capitalists get the best of what can be a useful and therapeutic substance.

But on with the show.

While anyone with any knowledge of the marijuana plant knows about it’s most notable chemical property (Tetrahydrocannabinol, or THC for the rest of us), few know about its sister chemical property (Cannabidiol, or THC). THC is responsible for the more euphoric traits associated with marijuana consumption.

However, THC is also increasingly thought to be a trigger when it comes to mental issues typically associated with marijuana use (everything from anxiety to the schizophrenia connection). Which is where it’s longstanding sister property CBD comes in. Whilst THC is psychoactive, CBD seems to play the role of a sort of regulator when it comes to the THC intoxication experience. If I understand it correctly, it allows for the high without the potentially mentally risky rough edges associated with primary THC exposure only.

Alone, cannabidiol already has many usages in the medical field. It is at times utilized as a pain reliever. It also has been found to have positive effects in terms of mitigation of epileptic seizures. It is also utilized as an anti-nauseant for use in cancer patients. At a glance, it would seem that the uses mirror those attributed to THC. The big difference being the lack of psychoactive properties.

The National Institutes of Health has an even more fascinating list of conditions that are positively influenced by CBD exposure.

-Anorexia

-Emesis

-Pain

-Inflammation

-Multiple Sclerosis

-Neurodegenerative Disorders (Parkinson’s, Huntington’s, Tourette’s, Alzheimer’s)

-Epilepsy

-Glaucoma

-Osteoporosis

-Schizophrenia

-Cardiovascular Disorders

-Cancer

-Obesity

-Metabolic Syndrome related disorders

Some overlap with what I already mentioned. But a whole lot more. Including some quite unexpected listings. None the less, all patients potentially benefit from what is known as Cannabinoid Agonists/Antagonists/Cannabinoid Related Compounds.

Let’s unpack that.

Cannabinoid Antagonist – Also known as an anti-cannabinoid, this is a cannabinoidergic drug which binds to cannabinoid receptors, preventing activation by the bodies native endocannabinoids. These include antagonists, inverse agonists, and antibodies to cannabinoid receptors.

Inverse Agonists – These bind to the same receptor as an agonist, but elicits a response that is opposite to that of an agonist.

Cannabinoid Related Compound – While harder to nail down than the previous 2, it looks to be anything originating from the cannabis plant. Therein are at least 400 compounds, 80 of which are unique to the cannabis plant alone. All of which react to the human endocannabinoid system in different ways.

It seems that CBD is a very useful property all to its own. However, I suspect that it is often lumped in with it’s far more commonly known sister property THC. I can attest to this myself, as the distinction certainly wasn’t exactly clear to me at first glance (even as a pro-cannabis proponent!). But I suppose this will get better with time and public exposure. Whilst the capitalists will certainly market the differences, hopefully, the research side can keep up.

I opened this piece with the bold claim that was the seemingly unknown Yin and Yang relationship between THC and CBD, as played out in the marijuana plant. I have yet to quantify this claim with anything but speculation. So I shall take care of that issue now.

It looks like CBD’s previous role (as it stands much of the time, these days) was in modulating receptor signalling associated with THC, helping to mitigate the anxiety or paranoia sometimes related to THC intoxication. One of the ways in which this is accomplished is by activation of serotonin receptors (which reduces anxiety). I would hazard to guess that this is also the reason why it is utilized in the treatment of schizophrenia.

For a more in-depth analysis of the science surrounding CBD (it is both fascinating and in its infancy!), visit:

https://www.projectcbd.org/science/how-cbd-works

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